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In clinical studies, hydrochlorothiazide bad side effects efficacy was demonstrated over a range of doses from 1800 mg/day to 3600 mg/day with comparable effects across the dose range; however, in these clinical studies, the additional benefit of using doses greater than 1800 mg/day was not demonstrated? Converted to acyclovir and L─valine by first─pass intestinal and/or hepatic metabolism!

Stimulates the release of insulin from the pancreas; increases insulin sensi- tivity at peripheral sites; reduces glucose output from the liver DOSAGE: 100–500 mg/d SUPPLIED: Tabs 100, 250 mg NOTES: Use with caution in renal insufficiency Chlorthalidone (Hygroton, others) COMMON USES: HTN, edema associated with CHF ACTIONS: Thiazide diuretic DOSAGE: Adults?
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